![]() Available hereĢ.“Mitosis.” Nature News, Nature Publishing Group. Reference:ġ.“Phases of Mitosis.” Khan Academy. This is the difference between prophase and metaphase. Both phases are important phases of cell division. Prophase is followed by metaphase, and during the metaphase, nuclear membrane completely breaks down, chromosomes align at the metaphase plate, and spindle fibres attach with centromeres of the chromosomes. Prophase is the first phase of M phase, and during the prophase, nuclear membrane starts to break, chromatin condenses into visible chromatids, spindle fibres form and chromosomes start to pair. M phase proceeds via four phases namely prophase, metaphase, anaphase and telophase. During the M phase, nuclear division occurs, and cytoplasm divides into two cells by creating two daughter cells. During the interphase, cell prepares for the cell division by accumulating nutrients, synthesizing proteins and replicating the DNA. Metaphase occurs between prophase and anaphase.Ĭell division occurs via three major phases namely interphase, M phase and cytokinesis. Prophase occurs between interphase and metaphase. Metaphase is the second phase of the M phase in which chromosomes line up in the centre of the cell attaching to spindle fibres.ĭuring prophase, chromatin condenses into chromosomes, the nuclear envelope breaks down, and spindles form at opposite “poles” of the cell.ĭuring the metaphase, spindle fully develops, and the chromosomes align at the metaphase plate, nuclear membrane disappears completely. Prophase is the first phase of M phase in which chromatids condense, and sister chromatids appear, and spindle fibres form. Afterwards, sister chromatids of each chromosome appear. Chromatin converts into discrete chromosomes. During the prophase, chromatin appears in a thick and condensed form. It is the first phase in which cell starts its nuclear division. Prophase is one of the phases of mitotic phase of the meiosis and mitosis. Side by Side Comparison – Prophase vs Metaphase in Tabular Form Similarities Between Prophase and Metaphaseĥ. Prophase is followed by metaphase and during the metaphase homologous chromosomes are arranged in the centre of the cell (equatorial plate), and the spindle fibres are attached to the chromosomes at the centromeres. Prophase is the first phase of M phase in which cell stops growth and starts to nuclear division. M phase proceeds via four main phases namely prophase, metaphase, anaphase and telophase. ![]() Mitotic phase or the M phase describes the nuclear division of the cell. Interphase, M phase and cytokinesis are three major phases of cell cycle. The key difference between prophase and metaphase is that, in prophase, chromosomes condense and the spindle fibre forms while ,in metaphase, chromosomes line up in the centre of the cell and centromeres attach to the spindle fibres.Ĭell cycle refers to the series of events happening in a cell till it produces new cells. Prophase is the first phase and metaphase is the second phase of the M phase in the cell cycle.
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